期刊简介
本刊是由广西医科大学主办的国内外公开发行的医学学术期刊。内容丰富，形式多样，科学性强，有实用性。主要设有论著、经验交流、调查研究、技术与方法、护理园地、病例报告等栏目。
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首页>广西医科大学学报杂志
- 杂志名称：广西医科大学学报杂志
- 主管单位：广西医科大学
- 主办单位：广西医科大学
- 国际刊号：1005-930X
- 国内刊号：45-1211/R
- 出版周期：双月刊
期刊荣誉：全国高校自然科学优秀学报期刊收录：知网收录(中), 上海图书馆馆藏, 国家图书馆馆藏, 维普收录(中), 统计源核心期刊(中国科技论文核心期刊), 万方收录(中)
Study on the interaction between polymorphisms of FOXO3A gene and environmental factors in longevity at Bama county,Guangxi province
Bingshuang Long；Min He；Xiangjuan Li；Jian Qin；Zhiyong Zhang
关键词：FoxO3a, Environmental Factors, Interaction, longevity, Bama county
摘要：Objective:To study the interaction between the polymorphisms of FOXO3A and the environmental factors in the longevity district of Bama county.Methods:Using Taqmaq probe,genotyping of FOXO3A gene was performed for 200 longevous elderly (aged 90-110)and 288 healthy controls (aged 48-89).The interaction between the polymorphisms of gene and environmental factors were analyzed by using conditional logistic regression.Results:Minor allele frequencies (MAF)of five known SNPs in FOXO3A gene were higher in cases than in controls (P＜0.05).There was a positive interction between minority alleles of rs2764264 in FOXO3A gene and the environment factors in the longevity district(OR=1 1.08,γ=1.075).Conclusion:Five SNPs of FOXO3A gene would be closely correlated with human longevity in Bama.The interaction between the polymorphisms of FOXO3A genes rs2764264 and the environment factors in the longevity district had synergy to longevity.The longevity phenomenon in Bama probably was the result of the interaction between gene and environmental factors.
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