期刊简介
本刊是由广西医科大学主办的国内外公开发行的医学学术期刊。内容丰富，形式多样，科学性强，有实用性。主要设有论著、经验交流、调查研究、技术与方法、护理园地、病例报告等栏目。
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首页>广西医科大学学报杂志
- 杂志名称：广西医科大学学报杂志
- 主管单位：广西医科大学
- 主办单位：广西医科大学
- 国际刊号：1005-930X
- 国内刊号：45-1211/R
- 出版周期：双月刊
期刊荣誉：全国高校自然科学优秀学报期刊收录：知网收录(中), 上海图书馆馆藏, 国家图书馆馆藏, 维普收录(中), 统计源核心期刊(中国科技论文核心期刊), 万方收录(中)
The effect of matrine against biofilm formation in Escherichia coli
Yuming Huang；Xi Peng；Yizheng Li；He Zhao；Ju Qin；Yashan Song；Qiaoyuan Wu；Yunhua Liao
关键词：matrine, Escherichia Coli, peritoneal dialysis catheter, biofilm
摘要：Objective:To investigate the effect of matrine against biofilm formation of Escherichia coli (E.coli) in the early stage.Methods:Biofilms of E.coli (ATCC25922) was induced by using a peritoneal dialysis catheter in 96-well plates.After treatment with matrine for 24 h,the formation of biofilm on the catheters was observed by scanning electron microscope.The expressions of the flagellar gene (fliC) and motility genes (motA and motB) were determined by qPCR,and the protein expression of fliC was detected by western blotting.Results:The biofilm formation of E.coli was suppressed by different concentrations (less than the minimal inhibitory concentration) of matrine,and the mRNA levels of motA and motB as well as the mRNA and protein expression levels of fliC were decreased in a dose-dependent manner.Conclusion:Matrine could inhibit biofilm formation of E.coli via downregulating the expression of motA,motB and fliC.
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