期刊简介
本刊是由广西医科大学主办的国内外公开发行的医学学术期刊。内容丰富，形式多样，科学性强，有实用性。主要设有论著、经验交流、调查研究、技术与方法、护理园地、病例报告等栏目。
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首页>广西医科大学学报杂志
- 杂志名称：广西医科大学学报杂志
- 主管单位：广西医科大学
- 主办单位：广西医科大学
- 国际刊号：1005-930X
- 国内刊号：45-1211/R
- 出版周期：双月刊
期刊荣誉：全国高校自然科学优秀学报期刊收录：知网收录(中), 上海图书馆馆藏, 国家图书馆馆藏, 维普收录(中), 统计源核心期刊(中国科技论文核心期刊), 万方收录(中)
Cepharanthine enhance radiosensitization of nasopharyngeal carcinoma cells through inhibition of DNA damage repair
Mengya Zhang；Tianjun Ma；Qingfeng Song；Huixia Lin；Wei Xiao；Meiqi Zhao；XinQing Liang；Ying Cui
关键词：CEP, nasopharyngeal carcinoma, RAD51, XRCC1, radiosensitization
摘要：Objective:Recent reports suggest that Cepharanthine(CEP),a natural alkaloid extracted from the roots of Stephania Cepharanthine Hayata,can inhibit the proliferation of various cancer cells,but few studies focus on its radiosensitization in nasopharyngeal carcinoma(NPC) cells.The aim of this study was to explore the radiosensitization effect and the potential mechanisms of CEP on nasopharyngeal carcinoma cell lines CNE-1 and CNE-2.Methods:The NPC cell lines CNE-1 and CNE-2 were treated with CEP (IC50) for 48 h before irration (IR);clonogenic survival was then assessed.The apoptosis and cell cycle progression were using flow cytometry.The DNA damage repair and cycle-regulating proteins were evaluated by Western blot analysis.Results:CEP could inhibit cell growth in both cell lines.The combination of CEP and radiation promote cell cycle G2/M phase arrest and apoptosis in CNE-1 and CNE-2 cells.DNA damage repair analysis showed that CEP has an inhibitory effect on DNA repair of CNE-1 and CNE-2 cells after radiation.Conclusion:CEP enhances tumor radioresponse through multiple mechanisms that may involve the halted cell cycle progression at G2/M phase and the inhibition of DNA repair after exposure to radiation.
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